NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

The IκB kinase (IKK) complex acts as a gatekeeper of canonical NF-κB signaling in response to upstream stimulation. IKK activation requires sensing of ubiquitin chains by the essential IKK regulatory subunit IKKγ/NEMO. However, it has remained enigmatic whether NEMO binding to Lys-63-linked or linea...

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Autors principals: Hadian, Kamyar, Griesbach, Richard A., Dornauer, Scarlett, Wanger, Tim M., Nagel, Daniel, Metlitzky, Moritz, Beisker, Wolfgang, Schmidt-Supprian, Marc, Krappmann, Daniel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138271/
https://ncbi.nlm.nih.gov/pubmed/21622571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.233163
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