Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essentia...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Vincendeau, Michelle, Hadian, Kamyar, Messias, Ana C., Brenke, Jara K., Halander, Jenny, Griesbach, Richard, Greczmiel, Ute, Bertossi, Arianna, Stehle, Ralf, Nagel, Daniel, Demski, Katrin, Velvarska, Hana, Niessing, Dierk, Geerlof, Arie, Sattler, Michael, Krappmann, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703965/
https://ncbi.nlm.nih.gov/pubmed/26740240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18934
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