Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essentia...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vincendeau, Michelle, Hadian, Kamyar, Messias, Ana C., Brenke, Jara K., Halander, Jenny, Griesbach, Richard, Greczmiel, Ute, Bertossi, Arianna, Stehle, Ralf, Nagel, Daniel, Demski, Katrin, Velvarska, Hana, Niessing, Dierk, Geerlof, Arie, Sattler, Michael, Krappmann, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703965/
https://ncbi.nlm.nih.gov/pubmed/26740240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18934
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