Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2

Glioblastoma is the most common and malignant form of primary astrocytoma. Upon investigation of the insulin-like growth factor (IGF) pathway, we found the IGF2BP3/IMP3 transcript and protein to be up-regulated in GBMs but not in lower grade astrocytomas (p < 0.0001). IMP3 is an RNA binding prote...

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Detalhes bibliográficos
Main Authors: Suvasini, Ramaswamy, Shruti, Bhargava, Thota, Balaram, Shinde, Sridevi Vijay, Friedmann-Morvinski, Dinorah, Nawaz, Zahid, Prasanna, Krishnarao Venkatesh, Thennarasu, Kandavel, Hegde, Alangar Sathyaranjandas, Arivazhagan, Arimappamagan, Chandramouli, Bangalore Ashwathnarayanarao, Santosh, Vani, Somasundaram, Kumaravel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138258/
https://ncbi.nlm.nih.gov/pubmed/21613208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178012
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