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Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish

Mutation within an ubiquitin E3 ligase gene can lead to a failure in Notch signaling, excessive neurons, and depletion of neural progenitor cells in mind bomb mutants. Using mib(hi904) zebrafish, we reported seizures and a down-regulation of GABA signaling pathway genes. A transcriptome analysis als...

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Detalhes bibliográficos
Main Authors: Hortopan, Gabriela A., Baraban, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137702/
https://ncbi.nlm.nih.gov/pubmed/21688347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22680
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