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Importazole, a small molecule inhibitor of the transport receptor importin-β

During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. A similar mechanism operates in mitosis to generate a gradient of active spindle assembly factors around mitotic chromosomes. Importin-β and RanGTP have been implicated in additional ce...

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Bibliografski detalji
Glavni autori: Soderholm, Jonathan F., Bird, Stephen L., Kalab, Petr, Sampathkumar, Yasaswini, Hasegawa, Keisuke, Uehara-Bingen, Michael, Weis, Karsten, Heald, Rebecca
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137676/
https://ncbi.nlm.nih.gov/pubmed/21469738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2000296
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