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Importazole, a small molecule inhibitor of the transport receptor importin-β
During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. A similar mechanism operates in mitosis to generate a gradient of active spindle assembly factors around mitotic chromosomes. Importin-β and RanGTP have been implicated in additional ce...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137676/ https://ncbi.nlm.nih.gov/pubmed/21469738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2000296 |
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