Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex

BACKGROUND: Spreading depolarizations that occur in patients with malignant stroke, subarachnoid/intracranial hemorrhage, and traumatic brain injury are known to facilitate neuronal damage in metabolically compromised brain tissue. The dramatic failure of brain ion homeostasis caused by propagating...

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Main Authors: Risher, W. Christopher, Lee, Mark R., Fomitcheva, Ioulia V., Hess, David C., Kirov, Sergei A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137632/
https://ncbi.nlm.nih.gov/pubmed/21789251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022351
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