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Using Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization

We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating th...

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Bibliografiske detaljer
Main Authors: Simon, Richard, Simon, Noah Robin
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137591/
https://ncbi.nlm.nih.gov/pubmed/21769160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spl.2010.12.018
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