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Using Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization
We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137591/ https://ncbi.nlm.nih.gov/pubmed/21769160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spl.2010.12.018 |
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