Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-β–Signaling Pathways Regulates the Innate Inflammatory Response

The PI3K pathway and its regulation of mammalian target of rapamycin complex 1 (mTORC1) and glycogen synthase kinase 3 (GSK3) play pivotal roles in controlling inflammation. In this article, we show that mTORC1 and GSK3-β converge and that the capacity of mTORC1 to affect the inflammatory response i...

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Main Authors: Wang, Huizhi, Brown, Jonathan, Gu, Zhen, Garcia, Carlos A., Liang, Ruqiang, Alard, Pascale, Beurel, Eléonore, Jope, Richard S., Greenway, Terrance, Martin, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137265/
https://ncbi.nlm.nih.gov/pubmed/21422248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002513
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