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Ribonuclease A: Revealing Structure–Function Relationships with Semisynthesis

Bovine pancreatic ribonuclease A (RNase A) catalyzes the cleavage of P–O(5′) bonds in RNA. Structural analyses had suggested that the active-site lysine residue (K41) may interact preferentially with the transition state for covalent bond cleavage, thus facilitating catalysis. Here, site-directed mu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Messmore, June M., Fuchs, Dana N., Raines, Ronald T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137125/
https://ncbi.nlm.nih.gov/pubmed/21732653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja00136a001
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