Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site

Mcl-1, a pro-survival member of the Bcl-2 family located at the mitochondrial outer membrane, is subject to constitutive ubiquitylation by the Bcl-2 homology 3-only E3 ligase, Mule/Lasu1, resulting in rapid steady-state degradation via the proteasome. Insertion of newly synthesized Mcl-1 into the mi...

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Detalhes bibliográficos
Main Authors: Warr, Matthew R., Mills, John R., Nguyen, Mai, Lemaire-Ewing, Stephanie, Baardsnes, Jason, Sun, Karen L. W., Malina, Abba, Young, Jason C., Jeyaraju, Danny V., O'Connor-McCourt, Maureen, Pellegrini, Luca, Pelletier, Jerry, Shore, Gordon C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137083/
https://ncbi.nlm.nih.gov/pubmed/21613222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218321
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