Antibody Recognition of a Human Chorionic Gonadotropin Epitope (hCGβ(66–80)) Depends on Local Structure Retained in the Free Peptide

Human chorionic gonadotropin (hCG) is an important biomarker in pregnancy and oncology, where it is routinely detected and quantified by specific immunoassays. Intelligent epitope selection is essential to achieving the required assay performance. We present binding affinity measurements demonstrati...

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Detalhes bibliográficos
Main Authors: Gregor, Craig R., Cerasoli, Eleonora, Schouten, James, Ravi, Jascindra, Slootstra, Jerry, Horgan, Adrian, Martyna, Glenn J., Ryadnov, Maxim G., Davis, Paul, Crain, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137075/
https://ncbi.nlm.nih.gov/pubmed/21592960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246637
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