Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages

Nicotine inhibits the release of TNF-α from macrophage through activation of STAT3. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts containing AU-rich elements (ARE) in 3′-untranslated region (3′-UTR). Here we show that in LPS-stimulated human macrophages the anti-inflamma...

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Detalhes bibliográficos
Main Authors: Joe, Yeonsoo, Kim, Hyo Jeong, Kim, Sena, Chung, Jiwha, Ko, Myoung Seok, Lee, Won Hyeok, Chang, Ki Churl, Park, Jeong Woo, Chung, Hun Taeg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137049/
https://ncbi.nlm.nih.gov/pubmed/21606497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204859
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