IL-1β Promotes TGF-β1 and IL-2 Dependent Foxp3 Expression in Regulatory T Cells

Earlier, we have shown that GM-CSF-exposed CD8α− DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1β can induce Foxp3+ Tregs leading to suppression of autoimmunity. Here, we examined the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells when activated in th...

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Main Authors: Ganesh, Balaji B., Bhattacharya, Palash, Gopisetty, Anupama, Sheng, Jianrong, Vasu, Chenthamarakshan, Prabhakar, Bellur S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136935/
https://ncbi.nlm.nih.gov/pubmed/21779356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021949
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