DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III

Two DNA vaccines were constructed encoding the ectodomain (domains I, II and III) of the DENV2 envelope protein (pE1D2) or only its domain III (pE2D2), fused to the human tissue plasminogen activator signal peptide (t-PA). The expression and secretion of recombinant proteins was confirmed in vitro i...

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Detalhes bibliográficos
Main Authors: Azevedo, Adriana S., Yamamura, Anna M. Y., Freire, Marcos S., Trindade, Gisela F., Bonaldo, Myrna, Galler, Ricardo, Alves, Ada M. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136928/
https://ncbi.nlm.nih.gov/pubmed/21779317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020528
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