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Multivalent Binding of Nanocarrier to Endothelial Cells under Shear Flow

We investigate the effects of particle size, shear flow, and resistance due to the glycocalyx on the multivalent binding of functionalized nanocarriers (NC) to endothelial cells (ECs). We address the much- debated issue of shear-enhanced binding by computing the binding free-energy landscapes of NC...

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Detalhes bibliográficos
Main Authors: Liu, Jin, Agrawal, Neeraj J., Calderon, Andres, Ayyaswamy, Portonovo S., Eckmann, David M., Radhakrishnan, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136762/
https://ncbi.nlm.nih.gov/pubmed/21767483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.05.063
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