A Novel Small Molecule Antagonist of Choline Kinase-α That Simultaneously Suppresses MAPK and PI3K/AKT Signaling

Choline kinase-α expression and activity are increased in multiple human neoplasms as a result of growth factor stimulation and activation of cancer-related signaling pathways. The product of choline kinase-α, phosphocholine, serves as an essential metabolic reservoir for the production of phosphati...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Clem, Brian F., Clem, Amy L., Yalcin, Abdullah, Goswami, Umesh, Arumugam, Sengodagounder, Telang, Sucheta, Trent, John O., Chesney, Jason
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136659/
https://ncbi.nlm.nih.gov/pubmed/21423211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.51
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares