A Novel Small Molecule Antagonist of Choline Kinase-α That Simultaneously Suppresses MAPK and PI3K/AKT Signaling

Choline kinase-α expression and activity are increased in multiple human neoplasms as a result of growth factor stimulation and activation of cancer-related signaling pathways. The product of choline kinase-α, phosphocholine, serves as an essential metabolic reservoir for the production of phosphati...

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Autori principali: Clem, Brian F., Clem, Amy L., Yalcin, Abdullah, Goswami, Umesh, Arumugam, Sengodagounder, Telang, Sucheta, Trent, John O., Chesney, Jason
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136659/
https://ncbi.nlm.nih.gov/pubmed/21423211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.51
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