Crystal Structure of Human Protein Tyrosine Phosphatase SHP-1 in the Open Conformation

SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases (PTPs) and generally acts as a negative regulator in a variety of cellular signaling pathways. Previously the crystal structures of the tail-truncated SHP-1 and SHP-2 revealed an autoinhibitory conformation. To understand the...

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Main Authors: Wang, Wei, Liu, Lijun, Song, Xi, Mo, Yi, Komma, Chandrasekhar, Bellamy, Henry D., Zhao, Zhizhuang Joe, Zhou, G. Wayne
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135737/
https://ncbi.nlm.nih.gov/pubmed/21465528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23125
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