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Crystal Structure of Human Protein Tyrosine Phosphatase SHP-1 in the Open Conformation
SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases (PTPs) and generally acts as a negative regulator in a variety of cellular signaling pathways. Previously the crystal structures of the tail-truncated SHP-1 and SHP-2 revealed an autoinhibitory conformation. To understand the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135737/ https://ncbi.nlm.nih.gov/pubmed/21465528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23125 |
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