Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation

BACKGROUND: Worldwide, lung cancer kills more people than breast, colon and prostate cancer combined. Alterations in macrophage number and function during lung tumorigenesis suggest that these immune effector cells stimulate lung cancer growth. Evidence from cancer models in other tissues suggests t...

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Hlavní autoři: Fritz, Jason M, Dwyer-Nield, Lori D, Malkinson, Alvin M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135566/
https://ncbi.nlm.nih.gov/pubmed/21699731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-76
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