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Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the common IL-4/IL-13R drives most mouse model pathophysiology, including airway hyperresponsiveness (AHR). However, the precise cellular mechanisms through which IL-4Rα indu...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135339/ https://ncbi.nlm.nih.gov/pubmed/21464224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100023 |
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