Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice

Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the common IL-4/IL-13R drives most mouse model pathophysiology, including airway hyperresponsiveness (AHR). However, the precise cellular mechanisms through which IL-4Rα indu...

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Bibliographische Detailangaben
Hauptverfasser: Perkins, Charles, Yanase, Noriko, Smulian, George, Gildea, Lucy, Orekov, Tatyana, Potter, Crystal, Brombacher, Frank, Aronow, Bruce, Wills-Karp, Marsha, Finkelman, Fred D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135339/
https://ncbi.nlm.nih.gov/pubmed/21464224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100023
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