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Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond
The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells. Binding of Syk to phosphorylated immunoreceptor tyrosine-based activation motifs (p-ITAM) of the receptor subunits results in conformational changes and tyrosine phosphorylation at multiple sites that leads to ac...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Hindawi Publishing Corporation
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135164/ https://ncbi.nlm.nih.gov/pubmed/21776385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/507291 |
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