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Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles

The one-pot hydrozirconation of allenes and nitriles followed by an in situ transmetalation of the allylzirconocene with dimethylzinc or zinc chloride provides functionalized homoallylic amines. An intramolecular version of this process leads to 3-aminotetrahydrofurans and 3-aminotetrahydropyrans.

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Autors principals: Wipf, Peter, Manojlovic, Marija D
Format: Artigo
Idioma:Inglês
Publicat: Beilstein-Institut 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135093/
https://ncbi.nlm.nih.gov/pubmed/21804878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.94
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