The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity.
Site-directed mutagenesis of the TGC codon in a cloned streptolysin O (SLO) gene exchanged the single Cys residue in SLO for either Ala or Ser. The parent wild-type SLO (SLO.Cys-530) and the SLO.Ala-530 and SLO.Ser-530 mutant toxins, expressed in Escherichia coli, were purified and analyzed. Wild-ty...
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| Publicado no: | Infect Immun |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313485/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2663727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.8.2553-2558.1989 |
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