The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity.

Site-directed mutagenesis of the TGC codon in a cloned streptolysin O (SLO) gene exchanged the single Cys residue in SLO for either Ala or Ser. The parent wild-type SLO (SLO.Cys-530) and the SLO.Ala-530 and SLO.Ser-530 mutant toxins, expressed in Escherichia coli, were purified and analyzed. Wild-ty...

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Hlavní autoři: Pinkney, M, Beachey, E, Kehoe, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1989
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC313485/
https://ncbi.nlm.nih.gov/pubmed/2663727
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