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NusA interaction with the α-subunit of E. coli RNA Polymerase is via the UP-element site and releases autoinhibition
Elongating E. coli RNAP is modulated by NusA protein. The C-terminal domain (CTD) of the RNAP α-subunit (αCTD) interacts with the acidic CTD 2 (AR2) of NusA, releasing the autoinhibitory blockade of the NusA S1-KH1-KH2 motif and allowing NusA to bind nascent nut spacer RNA. We determined the solutio...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134791/ https://ncbi.nlm.nih.gov/pubmed/21742261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.03.024 |
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