NusA interaction with the α-subunit of E. coli RNA Polymerase is via the UP-element site and releases autoinhibition

Elongating E. coli RNAP is modulated by NusA protein. The C-terminal domain (CTD) of the RNAP α-subunit (αCTD) interacts with the acidic CTD 2 (AR2) of NusA, releasing the autoinhibitory blockade of the NusA S1-KH1-KH2 motif and allowing NusA to bind nascent nut spacer RNA. We determined the solutio...

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Auteurs principaux: Schweimer, Kristian, Prasch, Stefan, Sujatha, Pagadala Santhanam, Bubunenko, Mikhail, Gottesman, Max E., Rösch, Paul
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134791/
https://ncbi.nlm.nih.gov/pubmed/21742261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.03.024
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