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Structural and mechanistic basis of Parl activity and regulation
The mitochondrial rhomboid protease Parl governs apoptosis, morphology, metabolism and might be implicated in Parkinson's disease, but the structural basis of its activity and complex regulation remain unknown. We report the discovery of γ-cleavage, a proteolytic event on the loop connecting th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134571/ https://ncbi.nlm.nih.gov/pubmed/21415861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.22 |
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