How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer

The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas. Moreover, environmental exposure to radiation also induces rearranged transforming RET “isoforms” that are found in papillary th...

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Detalhes bibliográficos
Main Authors: Prazeres, Hugo, Torres, Joana, Rodrigues, Fernando, Couto, Joana P., Vinagre, João, Sobrinho-Simões, Manuel, Soares, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134398/
https://ncbi.nlm.nih.gov/pubmed/21765992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/678357
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