Complexation and Calcium-Induced Conformational Changes in the Cardiac Troponin Complex Monitored by Hydrogen/Deuterium Exchange and FT-ICR Mass Spectrometry

Cardiac muscle contraction is regulated by the heterotrimeric complex: troponin. We apply solution-phase hydrogen/deuterium exchange monitored by FT-ICR mass spectrometry to study the structural dynamics and the Ca-induced conformational changes of the cardiac isoform of troponin, by comparing H/D e...

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Main Authors: Bou-Assaf, George M., Chamoun, Jean E., Emmett, Mark R., Fajer, Piotr G., Marshall, Alan G.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134279/
https://ncbi.nlm.nih.gov/pubmed/21765647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.08.023
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