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CPEB Control of NF-κB Nuclear Localization and Interleukin-6 Production Mediates Cellular Senescence
CPEB is a sequence-specific translational regulatory RNA binding protein that mediates cellular senescence in primary mouse and human cells. CPEB knockout mouse embryo fibroblasts (MEFs) bypass senescence and synthesize large amounts of interleukin-6 (IL-6) and many other cytokines, which is not the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133380/ https://ncbi.nlm.nih.gov/pubmed/21536657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05133-11 |
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