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CPEB Control of NF-κB Nuclear Localization and Interleukin-6 Production Mediates Cellular Senescence

CPEB is a sequence-specific translational regulatory RNA binding protein that mediates cellular senescence in primary mouse and human cells. CPEB knockout mouse embryo fibroblasts (MEFs) bypass senescence and synthesize large amounts of interleukin-6 (IL-6) and many other cytokines, which is not the...

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Main Authors: Groppo, Rachel, Richter, Joel D.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133380/
https://ncbi.nlm.nih.gov/pubmed/21536657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05133-11
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