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The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome Stability
The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells. Defects in RECQ5 lead to the accumulation of spontaneous DNA double-stranded breaks (DSBs) during replication, despite the fact that these cells are proficient in DSB repair by homologous recombination (HR). The reason for th...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133350/ https://ncbi.nlm.nih.gov/pubmed/21402780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01137-10 |
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