Genome-Wide Approaches Reveal Functional Interleukin-4-Inducible STAT6 Binding to the Vascular Cell Adhesion Molecule 1 Promoter

Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin-4 (IL-4) markedly induced vascular cell adhesion molecule 1 (VCAM-1), both in cultured endothelial cells and in the intact endothelium in mice. Com...

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Hauptverfasser: Tozawa, Hideto, Kanki, Yasuharu, Suehiro, Jun-ichi, Tsutsumi, Shuichi, Kohro, Takahide, Wada, Youichiro, Aburatani, Hiroyuki, Aird, William C., Kodama, Tatsuhiko, Minami, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133239/
https://ncbi.nlm.nih.gov/pubmed/21464207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01430-10
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