KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response

The transcription factor Nrf2 has emerged as a master regulator of cellular redox homeostasis. As an adaptive response to oxidative stress, Nrf2 activates the transcription of a battery of genes encoding antioxidants, detoxification enzymes, and xenobiotic transporters by binding the cis-antioxidant...

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Bibliographic Details
Main Authors: Sun, Zheng, Wu, Tongde, Zhao, Fei, Lau, Alexandria, Birch, Christina M., Zhang, Donna D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133232/
https://ncbi.nlm.nih.gov/pubmed/21383067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05036-11
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