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Identification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombe

Bortezomib/PS-341/Velcade, a proteasome inhibitor, is widely used to treat multiple myeloma. While several mechanisms of the cytotoxicity of the drug were proposed, the actual mechanism remains elusive. We aimed to identify genes affecting the cytotoxicity of Bortezomib in the fission yeast S.pombe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takeda, Kojiro, Mori, Ayaka, Yanagida, Mitsuhiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132776/
https://ncbi.nlm.nih.gov/pubmed/21760946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022021
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