Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

Multivesicular bodies (MVBs) are endocytic compartments that contain intraluminal vesicles formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, these vesicles contain pro-apoptotic Fas ligand (FasL), which may be secreted as ‘lethal exosomes' upon fusion of MVBs w...

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Autors principals: Alonso, R, Mazzeo, C, Rodriguez, M C, Marsh, M, Fraile-Ramos, A, Calvo, V, Avila-Flores, A, Merida, I, Izquierdo, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131963/
https://ncbi.nlm.nih.gov/pubmed/21252909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.184
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