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Repression of Puma by Scratch2 is required for neuronal survival during embryonic development
Although Snail factors promote cell survival in development and cancer, the tumor-suppressor p53 promotes apoptosis in response to stress. p53 and Snail2 act antagonistically to regulate p53 upregulated modulator of apoptosis (Puma) and cell death in hematopoietic progenitors following DNA damage. H...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131948/ https://ncbi.nlm.nih.gov/pubmed/21252910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.190 |
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