Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes

In this study, we evaluated the possible cross-talk between glucocorticoid (GC)-induced leucine zipper (Gilz) and caspase-8 in dexamethasone (Dex)-treated thymocytes. We determined that expression of Dex-induced Gilz protein was reduced when caspase-8 activity was inhibited, and this effect was not...

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Hauptverfasser: Delfino, D V, Spinicelli, S, Pozzesi, N, Pierangeli, S, Velardi, E, Bruscoli, S, Martelli, M P, Pettirossi, V, Falchi, L, Kang, T-b, Riccardi, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131874/
https://ncbi.nlm.nih.gov/pubmed/20671745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.86
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