AAV Delivery of Wild-Type Rhodopsin Preserves Retinal Function in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Autosomal dominant retinitis pigmentosa (ADRP) is frequently caused by mutations in RHO, the gene for rod photoreceptor opsin. Earlier, a study on mice carrying mutated rhodopsin transgenes on either RHO + / +  or RHO + /– backgrounds suggested that the amount of wild-type rhodopsin affected surviva...

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Bibliographische Detailangaben
Hauptverfasser: Mao, Haoyu, James, Thomas, Schwein, Alison, Shabashvili, Arseniy E., Hauswirth, William W., Gorbatyuk, Marina S., Lewin, Alfred S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131806/
https://ncbi.nlm.nih.gov/pubmed/21126223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.140
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