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Inhibition of glycosphingolipid biosynthesis induces cytokinesis failure
Although cells undergo dramatic shape changes during cytokinesis, the role of the plasma membrane and lipids is poorly understood. We report that inactivation of glucosyl ceramide synthase (GCS), either by RNAi or with the small molecule PPMP, causes failure of cleavage furrow ingression. Using mass...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131740/ https://ncbi.nlm.nih.gov/pubmed/21668028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja202804b |
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