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Mass spectrometry evidence for cisplatin as a protein cross-linking reagent
Cisplatin is a potent anti-cancer drug, which functions by cross-linking adjacent DNA guanine residues. However within one day of injection, 65~98% of the platinum in the blood plasma is protein-bound. It is generally accepted that cisplatin binds to methionine and histidine residues, but what is of...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131505/ https://ncbi.nlm.nih.gov/pubmed/21591778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac200861k |
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