Structure of the human histamine H(1) receptor complex with doxepin

The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine-H(1) receptor (H(1)R) antagonists are very effective drugs alleviating the symptoms of allergic reactions. Here we show the crystal structure...

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Autors principals: Shimamura, Tatsuro, Shiroishi, Mitsunori, Weyand, Simone, Tsujimoto, Hirokazu, Winter, Graeme, Katritch, Vsevolod, Abagyan, Ruben, Cherezov, Vadim, Liu, Wei, Han, Gye Won, Kobayashi, Takuya, Stevens, Raymond C., Iwata, So
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131495/
https://ncbi.nlm.nih.gov/pubmed/21697825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10236
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