Rapamycin Partially Mimics the Anticancer Effects of Calorie Restriction in a Murine Model of Pancreatic Cancer

Etiologic factors for pancreatic cancer, the fourth deadliest malignant neoplasm in the United States, include obesity and abnormal glucose metabolism. Calorie restriction (CR) and rapamycin each affect energy metabolism and cell survival pathways via inhibition of mammalian target of rapamycin (mTO...

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Main Authors: Lashinger, Laura M., Malone, Lauren M., Brown, Graham W., Daniels, Elizabeth A., Goldberg, Jason A., Otto, Glen, Fischer, Susan M., Hursting, Stephen D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131470/
https://ncbi.nlm.nih.gov/pubmed/21593197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0023
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