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Genetic Reduction of Insulin-like Growth Factor-1 Mimics the Anticancer Effects of Calorie Restriction on Cyclooxygenase-2–Driven Pancreatic Neoplasia

Risk of pancreatic cancer, the fourth deadliest cancer in the U.S., is increased by obesity. Calorie restriction (CR) prevents obesity, suppresses carcinogenesis in many models, and reduces serum levels of insulin-like growth factor (IGF)-1. In the present study, we examined the impact of CR on a mo...

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Detalhes bibliográficos
Main Authors: Lashinger, Laura M., Malone, Lauren M., McArthur, Mark J., Goldberg, Jason A., Daniels, Elizabeth A., Pavone, Amy, Colby, Jennifer K., Smith, Nicole C., Perkins, Susan N., Fischer, Susan M., Hursting, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131443/
https://ncbi.nlm.nih.gov/pubmed/21593196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0027
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