Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice

BACKGROUND: Excessive alcohol intake causes an increase in intestinal permeability that induces translocation of gut-derived lipopolysaccharide (LPS) to the portal vein. Increased LPS in the portal vein stimulates Kupffer cells through Toll-like receptor (TLR) 4 in the liver. Activated TLR4 signalin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Inokuchi, Sayaka, Tsukamoto, Hidekazu, Park, EekJoong, Liu, Zhang-Xu, Brenner, David A., Seki, Ekihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131439/
https://ncbi.nlm.nih.gov/pubmed/21463341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01487.x
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