Pathologic and Phenotypic Alterations in a Mouse Expressing a Connexin47 Missense Mutation That Causes Pelizaeus-Merzbacher–Like Disease in Humans

Gap junction channels are intercellular conduits that allow diffusional exchange of ions, second messengers, and metabolites. Human oligodendrocytes express the gap junction protein connexin47 (Cx47), which is encoded by the GJC2 gene. The autosomal recessive mutation hCx47M283T causes Pelizaeus-Mer...

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Main Authors: Tress, Oliver, Maglione, Marta, Zlomuzica, Armin, May, Dennis, Dicke, Nikolai, Degen, Joachim, Dere, Ekrem, Kettenmann, Helmut, Hartmann, Dieter, Willecke, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131295/
https://ncbi.nlm.nih.gov/pubmed/21750683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002146
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