Pathologic and Phenotypic Alterations in a Mouse Expressing a Connexin47 Missense Mutation That Causes Pelizaeus-Merzbacher–Like Disease in Humans

Gap junction channels are intercellular conduits that allow diffusional exchange of ions, second messengers, and metabolites. Human oligodendrocytes express the gap junction protein connexin47 (Cx47), which is encoded by the GJC2 gene. The autosomal recessive mutation hCx47M283T causes Pelizaeus-Mer...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Tress, Oliver, Maglione, Marta, Zlomuzica, Armin, May, Dennis, Dicke, Nikolai, Degen, Joachim, Dere, Ekrem, Kettenmann, Helmut, Hartmann, Dieter, Willecke, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131295/
https://ncbi.nlm.nih.gov/pubmed/21750683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002146
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge