Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques

BACKGROUND: We previously showed that the progression of atherosclerosis in the Reversa mouse (Ldlr(−/−)Apob(100/100)Mttp(fl/fl)Mx1Cre(+/+)) was arrested when the hyperlipidemia was normalized by inactivating the gene for microsomal triglyceride transfer protein. Here we tested whether atheroscleros...

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Bibliographic Details
Main Authors: Feig, Jonathan E., Parathath, Sajesh, Rong, James X., Mick, Stephanie L., Vengrenyuk, Yuliya, Grauer, Lisa, Young, Stephen G., Fisher, Edward A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131163/
https://ncbi.nlm.nih.gov/pubmed/21339485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.984146
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