Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9

BACKGROUND AND PURPOSE: Roscovitine, a cyclin-dependent kinase (CDK) inhibitor that induces tumour cell death, is under evaluation as an anti-cancer drug. By triggering leukocyte apoptosis, roscovitine can also enhance the resolution of inflammation. Beyond death-inducing properties, we tested wheth...

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Hlavní autoři: Berberich, Nina, Uhl, Bernd, Joore, Jos, Schmerwitz, Ulrike K, Mayer, Bettina A, Reichel, Christoph A, Krombach, Fritz, Zahler, Stefan, Vollmar, Angelika M, Fürst, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130954/
https://ncbi.nlm.nih.gov/pubmed/21391976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01309.x
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